概述

  • 产品名称Anti-Apoptosis inhibitor 5抗体
    参阅全部 Apoptosis inhibitor 5 一抗
  • 描述
    小鼠单克隆抗体to Apoptosis inhibitor 5
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 400-504 of Human Apoptosis inhibitor 5

性能

应用

Our Abpromise guarantee covers the use of ab56392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
    • 组织特异性Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
    • 序列相似性Belongs to the API5 family.
    • 结构域Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
    • 细胞定位Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AAC 11 antibody
      • AAC-11 antibody
      • AAC11 antibody
      • Antiapoptosis clone 11 protein antibody
      • API 5 antibody
      • API-5 antibody
      • api5 antibody
      • API5 like 1 antibody
      • API5_HUMAN antibody
      • API5L1 antibody
      • Apoptosis inhibitor 5 antibody
      • Cell migration inducing gene 8 protein antibody
      • Cell migration-inducing gene 8 protein antibody
      • Fibroblast growth factor 2 interacting factor 2 antibody
      • Fibroblast growth factor 2-interacting factor antibody
      • FIF antibody
      • MIG 8 antibody
      • MIG8 antibody
      • Migration inducing protein MIG8 antibody
      • Protein XAGL antibody
      see all

    Anti-Apoptosis inhibitor 5 antibody 图像

    • Apoptosis inhibitor 5 antibody (ab56392) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.


    • Predicted band size : 58 kDa

    Anti-Apoptosis inhibitor 5 antibody (ab56392)参考文献

    This product has been referenced in:
    • Garcia-Jove Navarro M  et al. Api5 contributes to E2F1 control of the G1/S cell cycle phase transition. PLoS One 8:e71443 (2013). WB . Read more (PubMed: 23940755) »
    • Schlundt A  et al. Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol Cell Proteomics 8:2474-86 (2009). Read more (PubMed: 19542561) »

    See all 2 Publications for this product

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