概述

  • 产品名称
    Anti-Apolipoprotein CIII抗体(HRP)
    参阅全部 Apolipoprotein CIII 一抗
  • 描述
    山羊多克隆抗体to Apolipoprotein CIII (HRP)
  • 偶联物
    HRP
  • 特异性
    Specifically binds to human Apolipoprotein CIII.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native APO CIII protein (purified) (Human)

  • 常规说明


    The antibody can be used for detection of human apo CIII in plasma, immunoassays and immunoblots.

性能

应用

Our Abpromise guarantee covers the use of ab27624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1500 - 1/6000.
WB 1/1500 - 1/6000. Predicted molecular weight: 11 kDa.

The antibody can be used to detect human Apolipoprotein CI in plasma, immunoassays and immunoblots.

靶标

  • 功能
    Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
  • 组织特异性
    Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
  • 疾病相关
    Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
  • 序列相似性
    Belongs to the apolipoprotein C3 family.
  • 翻译后修饰
    O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APOC3 antibody
    • APO C3 antibody
    • Apo CIII antibody
    • Apo-CIII antibody
    • APOC 3 antibody
    • ApoC III antibody
    • ApoC-III antibody
    • APOC3 antibody
    • APOC3_HUMAN antibody
    • ApoCIII antibody
    • Apolipoprotein C III antibody
    • Apolipoprotein C-III antibody
    • Apolipoprotein C3 antibody
    • ApolipoproteinCIII antibody
    • MGC150353 antibody
    see all

实验方案

文献

This product has been referenced in:
  • Mak AC  et al. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol 71:1228-36 (2014). Read more (PubMed: 25111166) »
  • Park KH  et al. Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity. J Gerontol A Biol Sci Med Sci 65:600-10 (2010). Sandwich ELISA . Read more (PubMed: 20421239) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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