存放说明 Shipped at 4°C. Store at +4°C.
存储溶液 Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10mg/ml BSA, 0.1M Sodium chloride, 50mM PBS, pH 7.4
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纯度 Immunogen affinity purified
纯化说明 Human Apolipoprotein CIII-Sepharose TM affinity column.
Primary antibody说明 The antibody can be used for detection of human apo CIII in plasma, immunoassays and immunoblots.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1500 - 1/6000.
1/1500 - 1/6000. Predicted molecular weight: 11 kDa.
The antibody can be used to detect human Apolipoprotein CI in plasma, immunoassays and immunoblots.
功能 Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
组织特异性 Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
疾病相关 Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
序列相似性 Belongs to the apolipoprotein C3 family.
翻译后修饰 O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
Information by UniProt
APO C3 antibody
Apo CIII antibody
Anti-Apolipoprotein CIII antibody (HRP) (ab27624)参考文献
This product has been referenced in:
et al. Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity. J Gerontol A Biol Sci Med Sci 65:600-10 (2010).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"