Anti-Apolipoprotein CI抗体(ab7617)

概述

  • 产品名称Anti-Apolipoprotein CI抗体
    参阅全部 Apolipoprotein CI 一抗
  • 描述
    山羊多克隆抗体to Apolipoprotein CI
  • 特异性Typically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein C-I and has negligible cross-reactivity with Type A-I, A-II, B, C-II, C-III, E and J apoLipoproteins.
  • 经测试应用适用于: Dot blot, ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length synthetic apoLipoprotein Type C-I (purified).

  • 常规说明This antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.

性能

应用

Our Abpromise guarantee covers the use of ab7617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot 1/5000 - 1/10000.
ELISA 1/4000 - 1/8000.
WB 1/1000.

靶标

  • 功能Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.
  • 组织特异性Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.
  • 序列相似性Belongs to the apolipoprotein C1 family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APO C1 antibody
    • Apo CI antibody
    • Apo-CIB antibody
    • Apo-CIB' antibody
    • APOC 1 antibody
    • ApoC I antibody
    • ApoC-IB antibody
    • ApoC-IB' antibody
    • APOC1 antibody
    • APOC1_HUMAN antibody
    • APOC1B antibody
    • Apolipoprotein C I antibody
    • Apolipoprotein C I variant I antibody
    • Apolipoprotein C-I antibody
    • Apolipoprotein C1 antibody
    • Apolipoprotein CI antibody
    • ApolipoproteinC I antibody
    • ApolipoproteinCI antibody
    • Truncated apolipoprotein C-I antibody
    see all

Anti-Apolipoprotein CI antibody (ab7617)参考文献

ab7617 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your phone call. I enquired with the originator of this antibody and it turns out that ab7617 has not yet been tested for application in IHC. There was an error on the datasheet which I have updated and I apologize for any confusion. This...

Read More

Thank you for your enquiry. The Apo C1 is purified from Human plasma by density gradient ultracentrifugation and HPLC. The protocol of the purification is proprietary. A general WB protocol is followed. This product has been assayed against 1...

Read More

Thank you for your enquiry. The antibody was tested in WB (6.6kDa) and Elisa. The sample tested against was purified Human apoC1 protein. I hope this information helps, please do not hesitate to contact us if you need any more advice or informat...

Read More

I'm sorry to hear you are having problems with ab7617 in WB. I would like to recommend incubating the primary antibody overnight at 4C to promote binding of the antibody to the protein and using ECL+ as a detection kit as this is more sensitive than E...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"