Anti-Apolipoprotein A V抗体- Aminoterminal end (ab55977)

概述

  • 产品名称Anti-Apolipoprotein A V抗体- Aminoterminal end
    参阅全部 Apolipoprotein A V 一抗
  • 描述
    兔多克隆抗体to Apolipoprotein A V - Aminoterminal end
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to N terminal residues of human Apolipoprotein A V

性能

应用

Our Abpromise guarantee covers the use of ab55977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
  • 组织特异性Liver and plasma.
  • 疾病相关Defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750].mFamilial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
    Defects in APOA5 are a cause of hyperlipoproteinemia type 5 (HLPP5) [MIM:144650]. HLPP5 is characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A) [MIM:232200].
  • 序列相似性Belongs to the apolipoprotein A1/A4/E family.
  • 翻译后修饰Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apo-AV antibody
    • ApoA-V antibody
    • Apoa5 antibody
    • APOA5_HUMAN antibody
    • ApoAV antibody
    • Apolipoprotein A-V antibody
    • Apolipoprotein A5 antibody
    • RAP3 antibody
    • Regeneration associated protein 3 antibody
    • Regeneration-associated protein 3 antibody
    see all

Anti-Apolipoprotein A V antibody - Aminoterminal end (ab55977)参考文献

ab55977 has not yet been referenced specifically in any publications.

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