Anti-Apolipoprotein A V抗体[2G1H11, 1F1E8] (ab115772)

概述

  • 产品名称Anti-Apolipoprotein A V抗体[2G1H11, 1F1E8]
    参阅全部 Apolipoprotein A V 一抗
  • 描述
    小鼠单克隆抗体[2G1H11, 1F1E8] to Apolipoprotein A V
  • 经测试应用适用于: Sandwich ELISA, WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified recombinant fragment of Human Apolipoprotein A V expressed in E. Coli.

  • 阳性对照
    • Human serum; Recombinant Human Apolipoprotein A V protein.

性能

应用

Our Abpromise guarantee covers the use of ab115772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA 1/10000.
WB 1/500 - 1/2000. Predicted molecular weight: 41 kDa.
ICC/IF 1/200 - 1/1000.

靶标

  • 功能Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
  • 组织特异性Liver and plasma.
  • 疾病相关Defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750].mFamilial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
    Defects in APOA5 are a cause of hyperlipoproteinemia type 5 (HLPP5) [MIM:144650]. HLPP5 is characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A) [MIM:232200].
  • 序列相似性Belongs to the apolipoprotein A1/A4/E family.
  • 翻译后修饰Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apo-AV antibody
    • ApoA-V antibody
    • Apoa5 antibody
    • APOA5_HUMAN antibody
    • ApoAV antibody
    • Apolipoprotein A-V antibody
    • Apolipoprotein A5 antibody
    • RAP3 antibody
    • Regeneration associated protein 3 antibody
    • Regeneration-associated protein 3 antibody
    see all

Anti-Apolipoprotein A V antibody [2G1H11, 1F1E8] 图像

  • Sandwich ELISA using antibody pair to detect human Apolipoprotein A V protein.
  • Anti-Apolipoprotein A V antibody [2G1H11, 1F1E8] (ab115772) at 1/500 dilution + Human serum

    Predicted band size : 41 kDa
  • Anti-Apolipoprotein A V antibody [2G1H11, 1F1E8] (ab115772) at 1/500 dilution + Human recombinant Apolipoprotein A V protein

    Predicted band size : 41 kDa

Anti-Apolipoprotein A V antibody [2G1H11, 1F1E8] (ab115772)参考文献

ab115772 has not yet been referenced specifically in any publications.

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