Anti-Apolipoprotein A II抗体(ab7615)

概述

  • 产品名称Anti-Apolipoprotein A II抗体
    参阅全部 Apolipoprotein A II 一抗
  • 描述
    山羊多克隆抗体to Apolipoprotein A II
  • 特异性Typically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein A-II and has negligible cross-reactivity with Type A-I, B, C-I, C-II, C-III, E and J apoLipoproteins.
  • 经测试应用适用于: Dot blot, ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native apoLipoprotein Type A-II (purified).

  • 常规说明This antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.

性能

应用

Our Abpromise guarantee covers the use of ab7615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot 1/5000 - 1/10000.
ELISA 1/4000 - 1/8000.
WB Use at an assay dependent dilution.

靶标

  • 功能May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
  • 组织特异性Plasma; synthesized in the liver and intestine.
  • 序列相似性Belongs to the apolipoprotein A2 family.
  • 翻译后修饰Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APO A2 antibody
    • Apo AII antibody
    • Apo-AII antibody
    • APOA 2 antibody
    • ApoA II antibody
    • ApoA-II antibody
    • APOA2 antibody
    • APOA2_HUMAN antibody
    • APOAII antibody
    • Apolipoprotein A II antibody
    • Apolipoprotein A-II(1-76) antibody
    • Apolipoprotein A2 antibody
    • Apolipoprotein AII antibody
    • ApolipoproteinA II antibody
    • OTTHUMP00000032244 antibody
    see all

Anti-Apolipoprotein A II antibody (ab7615)参考文献

This product has been referenced in:
  • Ye GD  et al. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors. Gastroenterology N/A:N/A (2015). Read more (PubMed: 26619963) »
  • Kasthuri RS  et al. Extraordinary apolipoprotein oxidation in chronic hepatitis C and liver cirrhosis. Mol Cell Proteomics : (2007). WB ; Human . Read more (PubMed: 17709793) »

See all 2 Publications for this product

Product Wall

Thank you for your enquiry and your interest in our products. We would like to confirm that this antibody can bind ApoAII in intact HDL particles.

The immunogen is derived from human plasma. So far, it has only been tested for cross-reactivity with human.

17.4 kDa.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"