Anti-Apolipoprotein A II抗体(ab7615)

概述

  • 产品名称
    Anti-Apolipoprotein A II抗体
    参阅全部 Apolipoprotein A II 一抗
  • 描述
    山羊多克隆抗体to Apolipoprotein A II
  • 特异性
    Typically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein A-II and has negligible cross-reactivity with Type A-I, B, C-I, C-II, C-III, E and J apoLipoproteins.
  • 经测试应用
    适用于: Dot blot, ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native apoLipoprotein Type A-II (purified).

  • 常规说明
    This antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.

性能

应用

Our Abpromise guarantee covers the use of ab7615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot 1/5000 - 1/10000.
ELISA 1/4000 - 1/8000.
WB Use at an assay dependent dilution.

靶标

  • 功能
    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
  • 组织特异性
    Plasma; synthesized in the liver and intestine.
  • 序列相似性
    Belongs to the apolipoprotein A2 family.
  • 翻译后修饰
    Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APO A2 antibody
    • Apo AII antibody
    • Apo-AII antibody
    • APOA 2 antibody
    • ApoA II antibody
    • ApoA-II antibody
    • APOA2 antibody
    • APOA2_HUMAN antibody
    • APOAII antibody
    • Apolipoprotein A II antibody
    • Apolipoprotein A-II(1-76) antibody
    • Apolipoprotein A2 antibody
    • Apolipoprotein AII antibody
    • ApolipoproteinA II antibody
    • OTTHUMP00000032244 antibody
    see all

实验方案

文献

This product has been referenced in:
  • Ye GD  et al. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors. Gastroenterology N/A:N/A (2015). Read more (PubMed: 26619963) »
  • Kasthuri RS  et al. Extraordinary apolipoprotein oxidation in chronic hepatitis C and liver cirrhosis. Mol Cell Proteomics : (2007). WB ; Human . Read more (PubMed: 17709793) »

See all 2 Publications for this product

客户评价及客户问答

Thank you for your enquiry and your interest in our products. We would like to confirm that this antibody can bind ApoAII in intact HDL particles.

The immunogen is derived from human plasma. So far, it has only been tested for cross-reactivity with human.

17.4 kDa.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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