概述

  • 产品名称Anti-APOB48R抗体
    参阅全部 APOB48R 一抗
  • 描述
    兔多克隆抗体to APOB48R
  • 经测试应用适用于: WB, IHC-P, RIDmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Mouse very low density lipoprotein.

  • 阳性对照
    • Human Liver tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab125128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 516 kDa.
IHC-P 1/100.
RID Use at an assay dependent concentration.

靶标

  • 功能Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
  • 组织特异性Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
  • 翻译后修饰There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).
  • 细胞定位Cell membrane. Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
  • Information by UniProt
  • 数据库链接
  • 别名
    • apo b-100 antibody
    • APOB antibody
    • apoB-48R antibody
    • APOBR antibody
    • APOBR_HUMAN antibody
    • Apolipoprotein B receptor antibody
    • Apolipoprotein B-100 receptor antibody
    • Apolipoprotein B-48 receptor antibody
    • Apolipoprotein B48 receptor antibody
    see all

Anti-APOB48R antibody 图像

  • ab125128 at 1/100 dilution staining APOB48R in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-APOB48R antibody (ab125128)参考文献

ab125128 has not yet been referenced specifically in any publications.

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