Anti-APH1a抗体- N-terminal (ab60119)

概述

  • 产品名称Anti-APH1a抗体- N-terminal
    参阅全部 APH1a 一抗
  • 描述
    兔多克隆抗体to APH1a - N-terminal
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) at the N-terminal of the first 110 amino acids of human APH1a, conjugated to KLH

性能

应用

Our Abpromise guarantee covers the use of ab60119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 27 kDa (predicted molecular weight: 29 kDa).
IHC-P 1/50 - 1/100.

靶标

  • 功能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
  • 组织特异性Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
  • 序列相似性Belongs to the APH-1 family.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 6530402N02Rik antibody
    • AL138795.3 antibody
    • Anterior Pharynx Defective 1 antibody
    • Anterior pharynx defective 1 homolog A antibody
    • APH 1A antibody
    • Aph 1alpha antibody
    • APH-1a antibody
    • Aph-1alpha antibody
    • Aph1a antibody
    • APH1A gamma secretase subunit antibody
    • APH1A_HUMAN antibody
    • CGI 78 antibody
    • CGI78 antibody
    • Gamma secretase subunit APH 1A antibody
    • Gamma Secretase Subunit APH1a antibody
    • Gamma-secretase subunit APH-1A antibody
    • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
    • Presenilin Stabilization Factor antibody
    • Presenilin-stabilization factor antibody
    • PSF antibody
    • UNQ579/PRO1141 antibody
    see all

Anti-APH1a antibody - N-terminal 图像

  • Anti-APH1a antibody - N-terminal (ab60119) at 1/100 dilution

    Predicted band size : 29 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)
  • ab60119 at 1/100 dilution staining APH1a in human Hepatocarcinoma tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

Anti-APH1a antibody - N-terminal (ab60119)参考文献

ab60119 has not yet been referenced specifically in any publications.

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