概述

  • 产品名称Anti-Aph 1b抗体
    参阅全部 Aph 1b 一抗
  • 描述
    兔多克隆抗体to Aph 1b
  • 特异性ab116657 does not cross react to other component of gamma secretase complex nor with other proteins.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Caenorhabditis elegans
  • 免疫原

    Synthetic peptide corresponding to a region near the C terminal amino acids 235-257 of Human Aph 1b.

  • 常规说明


    ab116657 also labels the anterior pharynx defective 1 homolog B in C. elegans.

性能

应用

Our Abpromise guarantee covers the use of ab116657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 28 kDa.
ELISA 1/10000.

靶标

  • 功能Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • 组织特异性Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • 序列相似性Belongs to the APH-1 family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anterior pharynx defective 1 homolog B (C. elegans) antibody
    • Anterior pharynx defective 1 homolog B antibody
    • Anterior pharynx defective 1B like antibody
    • Anterior pharynx defective 1b short splicing variant antibody
    • APH 1B antibody
    • Aph 1beta antibody
    • APH-1b antibody
    • Aph-1beta antibody
    • Aph1 beta antibody
    • aph1b antibody
    • APH1B_HUMAN antibody
    • Aph1beta antibody
    • DKFZp564D0372 antibody
    • Gamma secretase subunit APH 1B antibody
    • Gamma secretase subunit APH1B antibody
    • Gamma secretase sununit antibody
    • Gamma-secretase subunit Aph-1b antibody
    • Presenilin stabilisation factor like antibody
    • Presenilin-stabilization factor-like antibody
    • PRO 1328 antibody
    • PRO1328 antibody
    • PSFL antibody
    • TAAV 688 antibody
    • TAAV688 antibody
    see all

Anti-Aph 1b antibody (ab116657)参考文献

This product has been referenced in:
  • Tanveer R  et al. The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-ß and in the Cortex of Aged Rats. J Biol Chem 287:34709-21 (2012). WB ; Rat . Read more (PubMed: 22891244) »

See 1 Publication for this product

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