概述

  • 产品名称Anti-APEX2抗体
    参阅全部 APEX2 一抗
  • 描述
    兔多克隆抗体to APEX2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide from the C terminal region of Human APEX2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
    Constituents: 0.1% Sodium phosphate, 0.45% Sodium chloride, 2.5% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab125211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa. The detection limit for ab125211 is approximately 1ng/lane under reducing and non-reducing conditions.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
  • 组织特异性Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
  • 序列相似性Belongs to the DNA repair enzymes AP/ExoA family.
  • 细胞定位Nucleus. Cytoplasm. Mitochondrion. Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AP endonuclease 2 antibody
    • AP endonuclease XTH2 antibody
    • APE 2 antibody
    • APE2 antibody
    • APEX 2 antibody
    • APEX L2 antibody
    • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antibody
    • APEX nuclease 2 antibody
    • APEX nuclease like 2 antibody
    • APEX nuclease-like 2 antibody
    • APEX2 antibody
    • APEX2_HUMAN antibody
    • APEXL 2 antibody
    • APEXL2 antibody
    • Apurinic apyrimidinic endonuclease 2 antibody
    • Apurinic-apyrimidinic endonuclease 2 antibody
    • Apurinic/apyrimidinic endonuclease 2 antibody
    • Apurinic/apyrimidinic endonuclease like 2 antibody
    • C430040P13Rik antibody
    • DNA (apurinic or apyrimidinic site) lyase 2 antibody
    • DNA apurinic or apyrimidinic site lyase 2 antibody
    • DNA-(apurinic or apyrimidinic site) lyase 2 antibody
    • EC 4.2.99.18 antibody
    • OTTHUMP00000023390 antibody
    • OTTHUMP00000061908 antibody
    • XTH 2 antibody
    • XTH2 antibody
    see all

Anti-APEX2 antibody (ab125211)参考文献

ab125211 has not yet been referenced specifically in any publications.

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