概述

  • 产品名称Anti-APCDD1抗体
    参阅全部 APCDD1 一抗
  • 描述
    小鼠多克隆抗体to APCDD1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human APCDD1 protein (NP_694545.1).

  • 阳性对照
    • APCDD1 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab73063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 59 kDa.

靶标

  • 功能Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • 组织特异性Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • 疾病相关Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • 序列相似性Belongs to the APCDD1 family.
  • 翻译后修饰N-Glycosylated.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Adenomatosis polyposis coli down regulated 1 antibody
    • Adenomatosis polyposis coli down regulated 1 protein antibody
    • Adenomatosis polyposis coli down-regulated 1 protein antibody
    • APCD1_HUMAN antibody
    • APCDD 1 antibody
    • APCDD1 antibody
    • B7323 antibody
    • DRAPC1 antibody
    • FP7019 antibody
    • HHS antibody
    • HTS antibody
    • hypoptrichosis simplex antibody
    • Protein APCDD1 antibody
    see all

Anti-APCDD1 antibody 图像

  • All lanes : Anti-APCDD1 antibody (ab73063) at 1 µg/ml

    Lane 1 : APCDD1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 59 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)

Anti-APCDD1 antibody (ab73063)参考文献

ab73063 has not yet been referenced specifically in any publications.

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