概述

  • 产品名称Anti-Apc6抗体
    参阅全部 Apc6 一抗
  • 描述
    兔多克隆抗体to Apc6
  • 特异性ab106495 is predicted not to cross-react with other APC family members.
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    An 18 amino acid synthetic peptide near the N terminus of Human Apc6 (NP_003894).

  • 阳性对照
    • Human liver tissue and lysate

性能

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应用

Our Abpromise guarantee covers the use of ab106495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 72 kDa.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the APC6/CDC16 family.
    Contains 7 TPR repeats.
  • 翻译后修饰Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • 细胞定位Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANAPC6 antibody
    • Anaphase promoting complex subunit 6 antibody
    • Anaphase-promoting complex subunit 6 antibody
    • Apc 6 antibody
    • APC6 antibody
    • CDC 16 antibody
    • CDC16 (cell division cycle 16 S. cerevisiae homolog) antibody
    • Cdc16 antibody
    • CDC16 homolog antibody
    • CDC16 protein antibody
    • CDC16_HUMAN antibody
    • CDC16Hs antibody
    • Cell division cycle 16 antibody
    • Cell division cycle 16 homolog antibody
    • Cell division cycle protein 16 homolog antibody
    • CUT9 antibody
    • Cyclosome subunit 6 antibody
    see all

Anti-Apc6 antibody 图像

  • Immunofluorescence of Apc6 in Human liver tissue with ab106495 at 20 ug/mL.

  • Lane 1 : Anti-Apc6 antibody (ab106495) at 1 µg/ml
    Lane 2 : Anti-Apc6 antibody (ab106495) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 72 kDa
  • ab106495, at 5 µg/ml, staining Apc6 in Human liver tissue by Immunohistochemistry.

Anti-Apc6 antibody (ab106495)参考文献

ab106495 has not yet been referenced specifically in any publications.

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