概述

  • 产品名称
    Anti-APC16抗体
  • 描述
    兔多克隆抗体to APC16
  • 经测试应用
    适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: VSGSSVTGSG FSVSDLAPPR KALFTYPKGA GEMLEDGSER FLCESVFSYQ VASTLKQVKH DQQVARMEKL AGLVEELEAD EWRFKPIEQ, corresponding to amino acids 13-101 of Human APC16.

  • 阳性对照
    • RT4, U-251 MG, Human Plasma and Human Liver lysates, Human colon tissue, U-2 OS cells

性能

应用

Our Abpromise guarantee covers the use of ab122416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

靶标

  • 功能
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the APC16 family.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • anapc16 antibody
    • Anaphase-promoting complex subunit 16 antibody
    • APC16 antibody
    • APC16_HUMAN antibody
    • bA570G20.3 antibody
    • C10orf104 antibody
    • CENP-27 antibody
    • centromere protein 27 antibody
    • Chromosome 10 open reading frame 104 antibody
    • Cyclosome subunit 16 antibody
    • metabolic syndrome-associated gene antibody
    • metabolic syndrome-associated protein antibody
    • MSAG antibody
    see all

图片

  • ab122416 at 1/150 dilution staining APC16 in Paraffin-embedded Human colon tissue by Immunohistochemistry.
  • Immunofluorescent staining of Human cell line U-2 OS using ab122416 at a concentration of 4 µg/ml. ab122416 staining is shown in green.

文献

ab122416 has not yet been referenced specifically in any publications.

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