Anti-Apc1 (phospho S688)抗体(ab61072)

概述

  • 产品名称Anti-Apc1 (phospho S688)抗体
    参阅全部 Apc1 一抗
  • 描述
    兔多克隆抗体to Apc1 (phospho S688)
  • 特异性ab61072 detects endogenous levels of APC1 only when phosphorylated at serine 688.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthesized phosphopeptide derived from human APC1 around the phosphorylation site of serine 688 (S-L-SP-P-V).

  • 阳性对照
    • Human breast carcinoma tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the APC1 family.
    Contains 4 PC repeats.
  • 翻译后修饰Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANAPC 1 antibody
    • Anapc1 antibody
    • Anaphase promoting complex subunit 1 antibody
    • anaphase-promoting complex 1 (meiotic checkpoint regulator) antibody
    • Anaphase-promoting complex subunit 1 antibody
    • Apc 1 antibody
    • APC1 antibody
    • APC1_HUMAN antibody
    • Cyclosome subunit 1 antibody
    • MCPR antibody
    • Meiotic checkpoint regulator antibody
    • Mitotic checkpoint regulator antibody
    • Protein Tsg 24 antibody
    • Protein Tsg24 antibody
    • Testis-specific gene 24 protein antibody
    • TSG 24 antibody
    • TSG24 antibody
    see all

Anti-Apc1 (phospho S688) antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab61072 at 1/50-1/100 dilution with or without immunising phosphopeptide.

Anti-Apc1 (phospho S688) antibody (ab61072)参考文献

ab61072 has not yet been referenced specifically in any publications.

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