This fast track antibody is not yet fully characterized. It is subject to these terms and conditions


  • 产品名称Anti-Apc1抗体
    参阅全部 Apc1 一抗
  • 描述
    兔多克隆抗体to Apc1

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特异性This affinity purified antibody is directed against human APC1 at the S355 residue. This antibody is pan reactive for both phosphorylated and non-phosphorylated APC1 at the S355 residue.
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide: SRAHSpPALG conjugated to KLH, corresponding to amino acids 351-359 of Human Apc1.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was purified against the non-phosphorylated form of the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


  • 应用说明peptide ELISA: 1/80000 (determined against 0.1 µg of the phosphorylated and non-phosphorylated forms of the immunizing peptide). Approximately equivalent staining is seen when both the phosphorylated and non-phosphorylated form of the immunizing peptide are bound to the ELISA plate.

    We have tested this antibody on various human tissue lysates and have as yet detected no bands of the appropriate size, however we have seen low background.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the APC1 family.
      Contains 4 PC repeats.
    • 翻译后修饰Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ANAPC 1 antibody
      • Anapc1 antibody
      • Anaphase promoting complex subunit 1 antibody
      • anaphase-promoting complex 1 (meiotic checkpoint regulator) antibody
      • Anaphase-promoting complex subunit 1 antibody
      • Apc 1 antibody
      • APC1 antibody
      • APC1_HUMAN antibody
      • Cyclosome subunit 1 antibody
      • MCPR antibody
      • Meiotic checkpoint regulator antibody
      • Mitotic checkpoint regulator antibody
      • Protein Tsg 24 antibody
      • Protein Tsg24 antibody
      • Testis-specific gene 24 protein antibody
      • TSG 24 antibody
      • TSG24 antibody
      see all

    Anti-Apc1 antibody (ab14207)参考文献

    ab14207 has not yet been referenced specifically in any publications.

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