概述

  • 产品名称Anti-APAF1抗体
    参阅全部 APAF1 一抗
  • 描述
    兔多克隆抗体to APAF1
  • 经测试应用适用于: IHC-FoFrmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from C terminal of Apaf-1(Human)

  • 阳性对照
    • Testis

性能

应用

Our Abpromise guarantee covers the use of ab46899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-FoFr
  • 应用说明IHC-Fo: 1/200.

    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM
    Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
    • 组织特异性Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
    • 序列相似性Contains 1 CARD domain.
      Contains 1 NB-ARC domain.
      Contains 13 WD repeats.
    • 结构域The CARD domain mediates interaction with APIP.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • APAF 1 antibody
      • Apaf-1 antibody
      • APAF_HUMAN antibody
      • Apaf1 antibody
      • Apoptotic peptidase activating factor 1 antibody
      • Apoptotic protease activating factor 1 antibody
      • Apoptotic protease activating factor antibody
      • Apoptotic protease-activating factor 1 antibody
      • CED 4 antibody
      • CED4 antibody
      • KIAA0413 antibody
      see all

    Anti-APAF1 antibody 图像

    • Human testis stained with ab46899 using the antibody at a dilution of 1:200

    Anti-APAF1 antibody (ab46899)参考文献

    ab46899 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"