Anti-APAF1抗体[5E11] (ab36824)

概述

  • 产品名称Anti-APAF1抗体[5E11]
    参阅全部 APAF1 一抗
  • 描述
    小鼠单克隆抗体[5E11] to APAF1
  • 经测试应用适用于: IHC (PFA fixed)more details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to amino acids near the carboxy terminus of human APAF1.

  • 阳性对照
    • K562 cells.

性能

应用

Our Abpromise guarantee covers the use of ab36824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC (PFA fixed)
  • 应用说明Immunohistochemistry (PFA fixed): Use at a concentration of 0.5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
    • 组织特异性Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
    • 序列相似性Contains 1 CARD domain.
      Contains 1 NB-ARC domain.
      Contains 13 WD repeats.
    • 结构域The CARD domain mediates interaction with APIP.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • APAF 1 antibody
      • Apaf-1 antibody
      • APAF_HUMAN antibody
      • Apaf1 antibody
      • Apoptotic peptidase activating factor 1 antibody
      • Apoptotic protease activating factor 1 antibody
      • Apoptotic protease activating factor antibody
      • Apoptotic protease-activating factor 1 antibody
      • CED 4 antibody
      • CED4 antibody
      • KIAA0413 antibody
      see all

    Anti-APAF1 antibody [5E11] 图像

    • ab36824 at 0.5µg/ml staining APAF1 in K562 cells by IHC

    Anti-APAF1 antibody [5E11] (ab36824)参考文献

    ab36824 has not yet been referenced specifically in any publications.

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