Anti-AP4M1抗体(ab96306)

概述

  • 产品名称Anti-AP4M1抗体
    参阅全部 AP4M1 一抗
  • 描述
    兔多克隆抗体to AP4M1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within the internal sequence amino acids 70-265 of Human AP4M1.

  • 阳性对照
    • 293T, A431, Jurkat, Raji cells

性能

应用

Our Abpromise guarantee covers the use of ab96306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.

靶标

  • 功能Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
  • 组织特异性Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.
  • 疾病相关Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3) [MIM:612936]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture.
  • 序列相似性Belongs to the adaptor complexes medium subunit family.
    Contains 1 MHD (mu homology) domain.
  • 结构域Interacts specifically with tyrosine-based sorting signals.
  • 细胞定位Golgi apparatus > trans-Golgi network. Membrane > coated pit. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Adapter-related protein complex 4 mu-1 subunit antibody
    • Adaptor related protein complex 4 mu 1 subunit antibody
    • Adaptor related protein complex AP 4 mu4 subunit antibody
    • Adaptor related protein complex AP4 mu4 subunit antibody
    • Adaptor-related protein complex AP-4, mu 1 antibody
    • AP 4 adapter complex mu subunit antibody
    • AP 4 complex subunit mu 1 antibody
    • AP-4 adapter complex mu subunit antibody
    • AP-4 complex subunit mu-1 antibody
    • AP4 adapter complex mu subunit antibody
    • AP4 complex subunit mu 1 antibody
    • AP4M1 antibody
    • AP4M1_HUMAN antibody
    • Ap4m4 antibody
    • CPSQ3 antibody
    • MU 4 antibody
    • Mu adaptin related protein 2 antibody
    • MU ARP2 antibody
    • Mu subunit of AP 4 antibody
    • Mu subunit of AP-4 antibody
    • Mu-adaptin-related protein 2 antibody
    • mu-ARP2 antibody
    • mu4 antibody
    • Mu4-adaptin antibody
    • MUARP 2 antibody
    • MUARP2 antibody
    • SPG50 antibody
    see all

Anti-AP4M1 antibody 图像

  • Anti-AP4M1 antibody (ab96306) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 50 kDa

Anti-AP4M1 antibody (ab96306)参考文献

ab96306 has not yet been referenced specifically in any publications.

Product Wall

Thanks for your patience.

Sorry for the confusion regarding the label of ab96306. I have confirmed that this antibody is not specific for phosphorylated AP4M1. It will detect total AP4M1.

Thanks for bringing this to our attention. P...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"