Anti-AP4M1抗体(ab96306)
Key features and details
- Rabbit polyclonal to AP4M1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-AP4M1抗体 -
描述
兔多克隆抗体to AP4M1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow -
免疫原
Recombinant fragment, corresponding to a region within the internal sequence amino acids 70-265 of Human AP4M1.
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阳性对照
- 293T, A431, Jurkat, Raji cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96306于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 50 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 50 kDa. |
靶标
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功能
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. -
组织特异性
Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung. -
疾病相关
Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3) [MIM:612936]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. -
序列相似性
Belongs to the adaptor complexes medium subunit family.
Contains 1 MHD (mu homology) domain. -
结构域
Interacts specifically with tyrosine-based sorting signals. -
细胞定位
Golgi apparatus > trans-Golgi network. Membrane > coated pit. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. - Information by UniProt
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数据库链接
- Entrez Gene: 768040 Cow
- Entrez Gene: 9179 Human
- Entrez Gene: 11781 Mouse
- Entrez Gene: 304344 Rat
- Omim: 602296 Human
- SwissProt: Q29RY8 Cow
- SwissProt: O00189 Human
- SwissProt: Q9JKC7 Mouse
see all -
别名
- Adapter-related protein complex 4 mu-1 subunit antibody
- Adaptor related protein complex 4 mu 1 subunit antibody
- Adaptor related protein complex AP 4 mu4 subunit antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab96306 被引用在 2 文献中.
- Contu VR et al. Lysosomal targeting of SIDT2 via multiple YxxF motifs is required for SIDT2 function in the process of RNautophagy. J Cell Sci 130:2843-2853 (2017). PubMed: 28724756
- Toh WH et al. Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway. Traffic 18:159-175 (2017). PubMed: 28000370