Anti-AP2 beta抗体[AP2b 1F3/8] (ab18113)


  • 产品名称Anti-AP2 beta抗体[AP2b 1F3/8]
    参阅全部 AP2 beta 一抗
  • 描述
    小鼠单克隆抗体[AP2b 1F3/8] to AP2 beta
  • 经测试应用适用于: WB, ELISA, IHC-Frmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Truncated AP-2 beta-protein prepared from bacteria.



Our Abpromise guarantee covers the use of ab18113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 50 kDa.
ELISA Use at an assay dependent concentration.
IHC-Fr 1/300.


  • 功能Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
  • 疾病相关Defects in TFAP2B are the cause of Char syndrome (CHAR) [MIM:169100]. CHAR is an autosomal dominant disorder characterized by patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies.
  • 序列相似性Belongs to the AP-2 family.
  • 翻译后修饰Sumoylated on Lys-21; which inhibits transcriptional activity.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activating enhancer binding protein 2 beta antibody
    • Activating enhancer-binding protein 2-beta antibody
    • AP 2B antibody
    • AP2 B antibody
    • AP2-beta antibody
    • AP2B antibody
    • AP2B_HUMAN antibody
    • AP2beta antibody
    • MGC21381 antibody
    • OTTHUMP00000039925 antibody
    • PDA2 antibody
    • TFAP 2B antibody
    • Tfap2b antibody
    • Transcription factor AP 2 beta antibody
    • Transcription factor AP-2-beta antibody
    • Transcription factor AP2 beta antibody
    see all

Anti-AP2 beta antibody [AP2b 1F3/8] 图像

  • ab18113 at 1/300 staining perfusion fixed rat brain tissue sections by IHC-Fr. Adult rat was perfused intracardially with paraformaldehyde 4% + 15% of a saturated solution of picric acid in PB 0.2M. The brain was post-fixed in the same fixative for 24 hours. Sections were cryoprotected with sucrose 20% and later frozen in OCT. Sections were incubated in free floating 12h with the primary antibody (1/300) and revealed with secondary antibody conjugated with Alexa Fluor ® 488 (1/2000). The staining obtained is restricted to the cytoplasm and consists of a small and thin punctate staining (white arrows). The pictures show the staining obtained in cortical neurons, with the X20 (top picture) and X40 (bottom picture) objective.

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Anti-AP2 beta antibody [AP2b 1F3/8] (ab18113)参考文献

This product has been referenced in:
  • Bökenkamp R  et al. Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells. PLoS One 9:e86892 (2014). IHC-P ; Rat . Read more (PubMed: 24489801) »
  • Ebauer M  et al. Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR. Oncogene 26:7267-81 (2007). WB ; Human . Read more (PubMed: 17525748) »

See all 2 Publications for this product

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Rat Tissue sections (Rat brain)
Specification Rat brain
Fixative Paraformaldehyde
Permeabilization No

Dr. Sophie Pezet

Verified customer

提交于 Jun 30 2009