Anti-AP2 alpha抗体[AP2a 8G8/5] (ab18112)


  • 产品名称
    Anti-AP2 alpha抗体[AP2a 8G8/5]
    参阅全部 AP2 alpha 一抗
  • 描述
    小鼠单克隆抗体[AP2a 8G8/5] to AP2 alpha
  • 宿主
  • 特异性
    Does not cross-react with AP2 beta or Ap2 gamma.
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Bacterial AP2 alpha/AP2 gamma fusion protein.

  • 阳性对照
    • Raji cells or breast carcinoma


  • 形式
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • 克隆
  • 克隆编号
    AP2a 8G8/5
  • 同种型
  • 研究领域


Our Abpromise guarantee covers the use of ab18112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 50 kDa.
IHC-P Use at an assay dependent concentration.


  • 功能
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.
  • 疾病相关
    Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major features include cutaneous anomalies, ocular anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair) anomalies.
  • 序列相似性
    Belongs to the AP-2 family.
  • 结构域
    The WW-binding motif mediates interaction with WWOX.
  • 翻译后修饰
    Sumoylated on Lys-10; which inhibits transcriptional activity.
  • 细胞定位
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activating enhancer binding protein 2 alpha antibody
    • Activating enhancer-binding protein 2-alpha antibody
    • Activator protein 2 antibody
    • AP 2 transcription factor antibody
    • AP 2alpha antibody
    • AP-2 antibody
    • AP-2 transcription factor antibody
    • AP2 antibody
    • AP2 Transcription Factor antibody
    • AP2-alpha antibody
    • AP2A_HUMAN antibody
    • AP2TF antibody
    • BOFS antibody
    • FLJ51761 antibody
    • TFAP 2 antibody
    • TFAP 2A antibody
    • TFAP2 antibody
    • TFAP2A antibody
    • Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody
    • Transcription factor AP-2-alpha antibody
    • Transcription factor AP2 alpha antibody
    see all


  • Immunohistochemical analysis of bladder cancer tissue, staining AP2 alpha with ab18112 at 1/40 dilution.


This product has been referenced in:
  • Nordentoft I  et al. Increased expression of transcription factor TFAP2a correlates with chemosensitivity in advanced bladder cancer. BMC Cancer 11:135 (2011). WB, IHC-P ; Human . Read more (PubMed: 21489314) »
  • Bennett KL  et al. AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. PLoS One 4:e6931 (2009). WB ; Human . Read more (PubMed: 19742317) »

See all 2 Publications for this product


Thank you for your enquiry. Raji cells or breast carcinoma can be used as a positive control for this antibody. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

Thank you for your enquiry. I received the following information from the source of this antibody - we "don't know the precise epitope recognized by 8G8, but due to the antigen used to raise this antibody, it must lie within the sequence: aa165 GINIPDQ...

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Thank you for your enquiry. All the information we have on species cross reactivity is specified on the datasheet, these are updated as soon as any new information is brought to our attention. As far as we are aware, cross reactivity with mouse h...

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