Anti-ANTXR2抗体(ab113523)

概述

  • 产品名称Anti-ANTXR2抗体
    参阅全部 ANTXR2 一抗
  • 描述
    山羊多克隆抗体to ANTXR2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Cow, Dog
  • 免疫原

    Synthetic peptide conjugated to KLH, from an internal sequence of Human ANTXR2 (NP_477520.2; NP_001139266.1).

  • 阳性对照
    • Human Kidney and Liver tissues; Human, Mouse and Rat Kidney lysates.

性能

应用

Our Abpromise guarantee covers the use of ab113523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 54 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 功能Necessary for cellular interactions with laminin and the extracellular matrix.
  • 组织特异性Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • 疾病相关Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • 序列相似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • 结构域Binding to PA seems to be effected through the VWA domain.
  • 细胞定位Secreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • Capillary morphogenesis protein 2 antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • HFS antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Anti-ANTXR2 antibody 图像

  • Anti-ANTXR2 antibody (ab113523) at 0.3 µg/ml + Mouse Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 54 kDa
  • ab113523, at 2.5µg/ml, staining ANTXR2 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab113523, at 2.5µg/ml, staining ANTXR2 in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-ANTXR2 antibody (ab113523)参考文献

ab113523 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (kidney, liver)
Specification kidney, liver
Blocking step HCl or none as blocking agent for 20 minute(s) · Concentration: 0.02% · Temperature: 20°C
Fixative none
Username

Frau Dr. Nadine Stokar

Verified customer

提交于 Oct 29 2013

The immunogenic peptide used to generate ab113523 is located in the extracellular region of ANTXR2.

Please do contact me if you have any additional questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"