概述

  • 产品名称Anti-ANTXR2抗体
    参阅全部 ANTXR2 一抗
  • 描述
    山羊多克隆抗体to ANTXR2
  • 特异性This antibody is expected to recognize both reported isoforms (NP_477520.2; NP_001139266.1).
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Cow, Dog
  • 免疫原

    Synthetic peptide:

    HEGLKLANEQIQK

    by a Cysteine residue linker, corresponding to internal sequence amino acids 121-133 of Human ANTXR2(NP_477520.2; NP_001139266.1)

  • 阳性对照
    • Human, Mouse and Rat kidney lysates

性能

应用

Our Abpromise guarantee covers the use of ab101711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 54 kDa.
Flow Cyt Use at an assay dependent concentration. PubMed: 24742682

ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.



ab37373-Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Necessary for cellular interactions with laminin and the extracellular matrix.
  • 组织特异性Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • 疾病相关Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • 序列相似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • 结构域Binding to PA seems to be effected through the VWA domain.
  • 细胞定位Secreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • Capillary morphogenesis protein 2 antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • HFS antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Anti-ANTXR2 antibody 图像

  • Anti-ANTXR2 antibody (ab101711) at 0.3 µg/ml + Mouse Kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 54 kDa

Anti-ANTXR2 antibody (ab101711)参考文献

This product has been referenced in:
  • Arévalo MT  et al. Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins. J Biol Chem 289:15730-15738 (2014). Flow Cyt, Blocking ; Human . Read more (PubMed: 24742682) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab101711.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"