Anti-Antithrombin III抗体[OTI8D5] (ab117851)


  • 产品名称Anti-Antithrombin III抗体[OTI8D5]
    参阅全部 Antithrombin III 一抗
  • 描述
    小鼠单克隆抗体[OTI8D5] to Antithrombin III
  • 经测试应用适用于: Flow Cyt, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length recombinant Human Antithrombin III (NP_000479) produced in HEK293T cells.

  • 阳性对照
    • HEK293T transfected cells
  • 常规说明

    The clone number has been updated from 8D5 to OTI8D5, both clone numbers name the same clone.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 1% BSA, 50% Glycerol, 48% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from mouse ascite fluid by affinity chromatography
  • 克隆单克隆
  • 克隆编号OTI8D5
  • 同种型IgG2b
  • 研究领域


Our Abpromise guarantee covers the use of ab117851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/100.

ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

WB Use at an assay dependent concentration. Predicted molecular weight: 52 kDa.


  • 功能Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
  • 组织特异性Found in plasma.
  • 疾病相关Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
  • 序列相似性Belongs to the serpin family.
  • 翻译后修饰Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位Secreted > extracellular space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANT3_HUMAN antibody
    • Antithrombin antibody
    • Antithrombin III antibody
    • Antithrombin-III antibody
    • AntithrombinIII antibody
    • AT 3 antibody
    • AT III antibody
    • AT3 antibody
    • AT3D antibody
    • ATIII antibody
    • Heparin cofactor I antibody
    • MGC22579 antibody
    • Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
    • Serine cysteine proteinase inhibitor clade C member 1 antibody
    • Serine proteinase inhibitor clade C member 1 antibody
    • Serpin C1 antibody
    • Serpin family C member 1 antibody
    • Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
    • SERPINC1 antibody
    • THPH7 antibody
    see all

Anti-Antithrombin III antibody [OTI8D5] 图像

  • Flow cytometry image using ab117851 at a 1/100 dilution, staining HEK293T cells transfected with Antithrombin III (Red), or an empty vector control plasmid (Blue).

Anti-Antithrombin III antibody [OTI8D5] (ab117851)参考文献

ab117851 has not yet been referenced specifically in any publications.

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Ab19170, ab46533 and ab117851 have all been validated in Flow Cyt and therefore are guaranteed to work in this application.

Regarding ab19170, cells were were fixed with 4% paraformaldehyde but not perm...

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