概述

  • 产品名称Anti-Antithrombin III抗体
    参阅全部 Antithrombin III 一抗
  • 描述
    鸡多克隆抗体to Antithrombin III
  • 特异性The antibody has been tested against purified human plasma antithrombin III protein. It has yet to be tested against whole plasma samples.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein (Human).

  • 阳性对照
    • Purified Human plasma antithrombin III protein.

性能

应用

Our Abpromise guarantee covers the use of ab19105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 49 kDa (predicted molecular weight: 53 kDa).
ELISA Use at an assay dependent dilution.

靶标

  • 功能Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
  • 组织特异性Found in plasma.
  • 疾病相关Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
  • 序列相似性Belongs to the serpin family.
  • 翻译后修饰Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位Secreted > extracellular space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANT3_HUMAN antibody
    • Antithrombin antibody
    • Antithrombin III antibody
    • Antithrombin-III antibody
    • AntithrombinIII antibody
    • AT 3 antibody
    • AT III antibody
    • AT3 antibody
    • AT3D antibody
    • ATIII antibody
    • Heparin cofactor I antibody
    • MGC22579 antibody
    • Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
    • Serine cysteine proteinase inhibitor clade C member 1 antibody
    • Serine proteinase inhibitor clade C member 1 antibody
    • Serpin C1 antibody
    • Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
    • SERPINC1 antibody
    • THPH7 antibody
    see all

Anti-Antithrombin III antibody 图像



  • Predicted band size : 53 kDa


    ab19105 at 1/2000 staining human plasma antithrombin III protein by Western blot.

Anti-Antithrombin III antibody (ab19105)参考文献

This product has been referenced in:
  • Papareddy P  et al. Antimicrobial effects of helix D-derived peptides of human antithrombin III. J Biol Chem 289:29790-800 (2014). Read more (PubMed: 25202017) »

See 1 Publication for this product

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