概述
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产品名称Anti-Antithrombin III抗体
参阅全部 Antithrombin III 一抗 -
描述羊多克隆抗体to Antithrombin III
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宿主Sheep
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经测试应用适用于: IHC-P, Immunodiffusion, Immunoelectrophoresis, Double Immunodiffusionmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat, Horse, Cat, Dog
不与反应:
Rabbit, Goat, Chicken, Guinea pig, Cow, Pig -
免疫原
Human Antithrombin III purified from plasma.
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阳性对照
- Human intestine tissue
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常规说明Reactivity against the sera of the listed species has been assessed by double diffusion using 10 ul of antisera against 1 ul of species sera.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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存储溶液pH: 7.40
Preservative: 0.1% Sodium azide
Constituents: 99% Glycine buffered saline, 0.1% EACA, 0.01% Benzamidine, 0.03% EDTA -
Concentration information loading... -
纯度DEAE-Chromatography
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克隆多克隆
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同种型IgG
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研究领域
应用
Our Abpromise guarantee covers the use of ab124259 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | Use a concentration of 5 µg/ml. | |
| Immunodiffusion | Use at an assay dependent dilution. RID: 6 ul antiserum/cm2 gel vs. 5 ul neat -1:10 dilution human plasma. | |
| Immunoelectrophoresis | Use at an assay dependent dilution. 100 ul antiserum vs. 5 ul plasma gives single arc. Note: The use of 3% PEG 6000 with 1.2% agarose in a suitable buffer (such as TBE or Tris-barbital pH >8.2) is recommended. | |
| Double Immunodiffusion | Use at an assay dependent dilution. 10 ul antiserum vs. 5 ul plasma. |
靶标
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功能Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
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组织特异性Found in plasma.
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疾病相关Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
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序列相似性Belongs to the serpin family.
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翻译后修饰Phosphorylation sites are present in the extracelllular medium.
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细胞定位Secreted > extracellular space.
- Information by UniProt
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数据库链接
- Entrez Gene: 462 Human
- Entrez Gene: 11905 Mouse
- Entrez Gene: 304917 Rat
- Omim: 107300 Human
- SwissProt: P01008 Human
- SwissProt: P32261 Mouse
- SwissProt: Q5M7T5 Rat
- Unigene: 75599 Human
see all -
别名
- ANT3_HUMAN antibody
- Antithrombin antibody
- Antithrombin III antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Antithrombin III antibody (ab124259)ab124259, at 5µg/ml, staining Antithrombin III in formalin-fixed, paraffin-embedded Human intestine vessels tissue.
文献
ab124259 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"