Anti-ANP抗体[M622709] (ab2093)

概述

  • 产品名称Anti-ANP抗体[M622709]
    参阅全部 ANP 一抗
  • 描述
    小鼠单克隆抗体[M622709] to ANP
  • 特异性Affinity Constant: 2.2 x 1010 L/M
  • 经测试应用适用于: Flow Cyt, RIA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Atrial Natriuretic Peptide whole molecule

性能

应用

Our Abpromise guarantee covers the use of ab2093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
RIA
IHC-P
  • 应用说明Flow Cyt: Use at an assay dependent dilution (PMID 20080656).
    IHC-P: Use at an assay dependent dilution.
    RIA: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
    • 疾病相关Atrial standstill 2
      Atrial fibrillation, familial, 6
    • 序列相似性Belongs to the natriuretic peptide family.
    • 翻译后修饰Cleaved by CORIN upon secretion to produce the functional hormone.
      Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ANF antibody
      • ANF_HUMAN antibody
      • ANP antibody
      • ATFB6 antibody
      • Atrial natriuretic factor antibody
      • Atrial natriuretic peptide antibody
      • Atriopeptin antibody
      • Cardiodilatin antibody
      • Cardiodilatin-related peptide antibody
      • Cardionatrin antibody
      • CDD ANF antibody
      • CDD antibody
      • CDD-ANF antibody
      • CDP antibody
      • Natriuretic peptide A antibody
      • Natriuretic peptide precursor A antibody
      • NPPA antibody
      • PND antibody
      • Prepronatriodilatin antibody
      see all

    Anti-ANP antibody [M622709] (ab2093)参考文献

    This product has been referenced in:
    • Therrien JP  et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . Read more (PubMed: 20080656) »

    See 1 Publication for this product

    Product Wall

    Abcam has not validated the combination of species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (Heart tissue including atrium)
    Antigen retrieval step None
    Permeabilization No
    Specification Heart tissue including atrium
    Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2000µg/mL · Temperature: 21D°C
    Fixative Formaldehyde
    Username

    Dr. Isabelle Miletich

    Verified customer

    提交于 Nov 04 2016

    Thank you for contacting us.


    I have attached the CoCs for ab14319, Anti-Urodilatin antibody and for ab2093 Anti-ANP antibody [M622709] as well the SDS for ab2093. I have also asked our documents team to create the SDS for ab14319. This w...

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    Thank you for your enquiry. Unfortunately, we do not have the protein that was used to make this antibody in our catalogue and I am afraid that I do not know if it is commercially available. I am sorry I can't be of more assistance in this occas...

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    Thank you for your enquiry. ab2093 was generated using Atrial Natriuretic Peptide whole molecule as the immunogen. The peptide sequence has accession number: CAA25700 and the following sequence: MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHL...

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    Clone M622709 is subtype IgG1. The approximate molecular weight of IgG1 is 148,000 daltons. This antibody has only been tested for application in Immunohistochemistry (Formalin-fixed paraffin-embedded sections)and Radioimmunoassay.

    Thank you for your enquiry and your interest in our products. As my colleagues possibly explained to you over the telephone, this antibody has not been tested for Western blot application. According to the datasheet, ab2093 recognizes the native for...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"