概述

  • 产品名称
  • 描述
    兔多克隆抗体to ANP
  • 经测试应用
    适用于: ICC, ICC/IF, RIAmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Guinea pig, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide:

    SLRRSSCFGGRIDRIGAQSGLGCNSFRY

    , corresponding to amino acids 1-28 of Rat ANP.

性能

应用

Our Abpromise guarantee covers the use of ab14348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution. PubMed: 20544856
RIA 1/3000.

靶标

  • 功能
    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 疾病相关
    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • 序列相似性
    Belongs to the natriuretic peptide family.
  • 翻译后修饰
    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • Cardiodilatin antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    see all

Anti-ANP antibody (ab14348)参考文献

This product has been referenced in:
  • Zheng C  et al. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol 8:222 (2017). WB ; Mouse . Read more (PubMed: 28487655) »
  • Christoforou N  et al. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PLoS One 8:e63577 (2013). ICC/IF . Read more (PubMed: 23704920) »

See all 3 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunocytochemistry
Sample
Rat Cell (astrocytes)
Specification
astrocytes
Fixative
Paraformaldehyde
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10%
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提交于 Jan 05 2006

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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