Recombinant fragment, corresponding to amino acids 177-329 of Human Annexin II (NM_001002857).
WB: SW480 and MDA-MB-231 cell lysates
IHC-P: Human colon carcinoma tissue
形式Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
功能Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
序列相似性Belongs to the annexin family. Contains 4 annexin repeats.
结构域A pair of annexin repeats may form one binding site for calcium and phospholipid.
翻译后修饰Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
细胞定位Secreted > extracellular space > extracellular matrix > basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.