概述

  • 产品名称Anti-ANKS1B抗体
    参阅全部 ANKS1B 一抗
  • 描述
    兔多克隆抗体to ANKS1B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 569-599 of Human ANKS1B (NP_064525.1 , NP_858056.2 , NP_690001.3).

  • 阳性对照
    • NCI-H292 cell line lysates.

性能

应用

Our Abpromise guarantee covers the use of ab116083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 138 kDa.

靶标

  • 功能Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
    Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
    Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • 组织特异性Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
  • 序列相似性Contains 7 ANK repeats.
    Contains 1 PID domain.
    Contains 2 SAM (sterile alpha motif) domains.
  • 翻译后修饰Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
  • 细胞定位Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AIDA antibody
    • AIDA-1 antibody
    • Amyloid-beta protein intracellular domain-associated protein 1 antibody
    • Anks1b antibody
    • ANKS2 antibody
    • Ankyrin repeat and sterile alpha motif domain containing 1B antibody
    • Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody
    • ANS1B_HUMAN antibody
    • Cajalin 2 antibody
    • E2A-PBX1-associated protein antibody
    • EB-1 antibody
    • EB1 antibody
    • MGC26087 antibody
    see all

Anti-ANKS1B antibody 图像

  • Anti-ANKS1B antibody (ab116083) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 138 kDa

Anti-ANKS1B antibody (ab116083)参考文献

ab116083 has not yet been referenced specifically in any publications.

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