Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
de Souza EE et al. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res13:4074-90 (2014).
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