概述

  • 产品名称Anti-ANKRD1抗体
    参阅全部 ANKRD1 一抗
  • 描述
    兔多克隆抗体to ANKRD1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human ANKRD1.

  • 阳性对照
    • This antibody gave a positive signal in Human heart tissue lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab88456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 36 kDa).

靶标

  • 功能May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
  • 组织特异性Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
  • 疾病相关Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
  • 序列相似性Contains 5 ANK repeats.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALRP antibody
    • ANKR1_HUMAN antibody
    • ANKRD 1 antibody
    • ANKRD1 antibody
    • Ankyrin repeat domain 1 (cardiac muscle) antibody
    • Ankyrin repeat domain containing protein 1 antibody
    • Ankyrin repeat domain-containing protein 1 antibody
    • bA320F15.2 antibody
    • C 193 antibody
    • C193 antibody
    • Cardiac ankyrin repeat protein antibody
    • CARP antibody
    • CVARP antibody
    • Cytokine inducible nuclear protein antibody
    • Cytokine-inducible gene C-193 protein antibody
    • Cytokine-inducible nuclear protein antibody
    • HA1A2 antibody
    • Liver ankyrin repeat domain 1 antibody
    • MCARP antibody
    • OTTHUMP00000020084 antibody
    see all

Anti-ANKRD1 antibody 图像

  • Anti-ANKRD1 antibody (ab88456) at 1 µg/ml + Human heart tissue lysate - total protein (ab29431) at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 36 kDa
    Observed band size : 32 kDa (why is the actual band size different from the predicted?)


    Exposure time : 30 seconds

Anti-ANKRD1 antibody (ab88456)参考文献

ab88456 has not yet been referenced specifically in any publications.

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