概述

  • 产品名称Anti-ANKRD1抗体
    参阅全部 ANKRD1 一抗
  • 描述
    兔多克隆抗体to ANKRD1
  • 特异性Detects endogenous levels of total ANKRD1 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide (Human) from an internal region

  • 阳性对照
    • COLO205 cell extract

性能

应用

Our Abpromise guarantee covers the use of ab64963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
ELISA 1/20000.

靶标

  • 功能May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
  • 组织特异性Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
  • 疾病相关Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
  • 序列相似性Contains 5 ANK repeats.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALRP antibody
    • ANKR1_HUMAN antibody
    • ANKRD 1 antibody
    • ANKRD1 antibody
    • Ankyrin repeat domain 1 (cardiac muscle) antibody
    • Ankyrin repeat domain containing protein 1 antibody
    • Ankyrin repeat domain-containing protein 1 antibody
    • bA320F15.2 antibody
    • C 193 antibody
    • C193 antibody
    • Cardiac ankyrin repeat protein antibody
    • CARP antibody
    • CVARP antibody
    • Cytokine inducible nuclear protein antibody
    • Cytokine-inducible gene C-193 protein antibody
    • Cytokine-inducible nuclear protein antibody
    • HA1A2 antibody
    • Liver ankyrin repeat domain 1 antibody
    • MCARP antibody
    • OTTHUMP00000020084 antibody
    see all

Anti-ANKRD1 antibody 图像

  • All lanes : Anti-ANKRD1 antibody (ab64963) at 1/500 dilution

    Lane 1 : COLO205 cell extract
    Lane 2 : COLO205 cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 36 kDa
    Observed band size : 36 kDa

Anti-ANKRD1 antibody (ab64963)参考文献

This product has been referenced in:
  • Band M  et al. The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. J Mol Evol 70:1-12 (2010). WB ; Rat, Other . Read more (PubMed: 19967343) »

See 1 Publication for this product

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