功能Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.
序列相似性Belongs to the ANKLE2 family. Contains 1 ANK repeat. Contains 1 LEM domain.
ankyrin repeat and LEM domain containing 2 antibody
Ankyrin repeat and LEM domain-containing protein 2 antibody
FLJ 22280 antibody
FLJ 36132 antibody
KIAA 0692 antibody
LEM domain containing 7 antibody
LEM domain-containing protein 4 antibody
LEMD 7 antibody
Anti-ANKLE2 antibody 图像
Western blot - ANKLE2 antibody (ab105193)
All lanes : Anti-ANKLE2 antibody (ab105193) at 0.1 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg Lane 2 : HeLa whole cell lysate at 15 µg Lane 3 : HeLa whole cell lysate at 5 µg Lane 4 : 293T whole cell lysate at 50 µg
Predicted band size : 104 kDa
Exposure time : 30 seconds
Immunoprecipitation - ANKLE2 antibody (ab105193)
ab105193 at 1 µg/ml staining ANKLE2 in HeLa whole cell lysate immunoprecipitated using ab105193 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with an exposure time: 10 seconds
Anti-ANKLE2 antibody (ab105193)参考文献
has not yet been referenced specifically in any publications.