Anti-Angiotensin II Type 1 Receptor抗体(ab59018)

概述

  • 产品名称Anti-Angiotensin II Type 1 Receptor抗体
    参阅全部 Angiotensin II Type 1 Receptor 一抗
  • 描述
    山羊多克隆抗体to Angiotensin II Type 1 Receptor
  • 特异性All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Sheep, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee
  • 免疫原

    Synthetic peptide:

    C-EIQKNKPRNDDIFK

    , corresponding to internal sequence amino acids 227-240 of Human Angiotensin II Type 1 Receptor

  • 阳性对照
    • Mouse Liver lysate.

性能

应用

Our Abpromise guarantee covers the use of ab59018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1:32,000.

    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 41 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    • 组织特异性Liver, lung, adrenal and adrenocortical adenomas.
    • 疾病相关Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    • 序列相似性Belongs to the G-protein coupled receptor 1 family.
    • 翻译后修饰C-terminal Ser or Thr residues may be phosphorylated.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AG2S antibody
      • Agtr 1 antibody
      • Agtr1 antibody
      • AGTR1_HUMAN antibody
      • Agtr1a antibody
      • AGTR1B antibody
      • Ang II antibody
      • Angiotensin II receptor type 1 antibody
      • Angiotensin II type-1 receptor antibody
      • Angiotensin receptor 1 antibody
      • Angiotensin receptor 1B antibody
      • AT 1B antibody
      • AT 1r antibody
      • AT1 antibody
      • At1a antibody
      • AT1AR antibody
      • AT1B antibody
      • AT1BR antibody
      • AT1R antibody
      • AT2R1 antibody
      • AT2R1A antibody
      • AT2R1B antibody
      • HAT1R antibody
      • Type 1 angiotensin II receptor antibody
      • Type 1B angiotensin II receptor antibody
      • Type-1 angiotensin II receptor antibody
      see all

    Anti-Angiotensin II Type 1 Receptor antibody 图像

    • Anti-Angiotensin II Type 1 Receptor antibody (ab59018) at 0.3 µg/ml + Mouse Liver lysate (35µg protein in RIPA buffer)

      Predicted band size : 41 kDa
      Observed band size : 38 kDa (why is the actual band size different from the predicted?)

    Anti-Angiotensin II Type 1 Receptor antibody (ab59018)参考文献

    This product has been referenced in:
    • Goyal R  et al. Antenatal maternal protein deprivation: sexually dimorphic programming of the pancreatic renin-angiotensin system. J Renin Angiotensin Aldosterone Syst 14:137-45 (2013). Read more (PubMed: 22898440) »

    See 1 Publication for this product

    Product Wall

    Abcam has not validated the combination of species/application used in this Abreview.
    Application Immunocytochemistry/ Immunofluorescence
    Sample Mouse Cell (Kidney)
    Specification Kidney
    Fixative Formaldehyde
    Permeabilization Yes - 0.5% TX100
    Blocking step Serum as blocking agent for 20 minute(s) · Concentration: 5% · Temperature: 25°C
    Username

    Herr Dr. Vladimir Milenkovic

    Verified customer

    提交于 Feb 17 2009

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"