Anti-Angiotensin I抗体[EPR3136Y] (ab81270)


  • 产品名称Anti-Angiotensin I抗体[EPR3136Y]
    参阅全部 Angiotensin I 一抗
  • 描述
    兔单克隆抗体[EPR3136Y] to Angiotensin I
  • 经测试应用适用于: WB, Flow Cyt, IPmore details
    不适用于: ICC or IHC-P
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) from near the N-terminus

  • 阳性对照
    • Human plasma lysate Fetal artery lysate
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab81270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200000 - 1/500000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).
Flow Cyt 1/50.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

IP 1/100.
  • 应用说明Is unsuitable for ICC or IHC-P.
  • 靶标

    • 功能Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
      Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
      Angiotensin-3 stimulates aldosterone release.
      Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
    • 组织特异性Expressed by the liver and secreted in plasma.
    • 疾病相关Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
      Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    • 序列相似性Belongs to the serpin family.
    • 翻译后修饰Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AGT antibody
      • Alpha 1 antiproteinase antitrypsin antibody
      • Ang I antibody
      • Ang II antibody
      • Ang III antibody
      • Angiotensin 1 antibody
      • Angiotensin I antibody
      • Angiotensin II antibody
      • Angiotensin III antibody
      • Angiotensin-3 antibody
      • Angiotensinogen antibody
      • Angiotensinogen serpin peptidase inhibitor clade A member 8 antibody
      • ANGT_HUMAN antibody
      • ANHU antibody
      • Des-Asp[1]-angiotensin II antibody
      • FLJ92595 antibody
      • FLJ97926 antibody
      • OTTHUMP00000035878 antibody
      • Pre angiotensinogen antibody
      • Serine or cysteine proteinase inhibitor antibody
      • Serpin A8 antibody
      • SERPINA8 antibody
      see all

    Anti-Angiotensin I antibody [EPR3136Y] 图像

    • All lanes : Anti-Angiotensin I antibody [EPR3136Y] (ab81270) at 1/500000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Fetal artery lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-rabbit HRP labelled IgG at 1/2000 dilution

      Predicted band size : 53 kDa
      Observed band size : 53 kDa
      Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.

    Anti-Angiotensin I antibody [EPR3136Y] (ab81270)参考文献

    ab81270 has not yet been referenced specifically in any publications.

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