Anti-Angiopoietin-like 4抗体(ab47046)

概述

  • 产品名称Anti-Angiopoietin-like 4抗体
    参阅全部 Angiopoietin-like 4 一抗
  • 描述
    兔多克隆抗体to Angiopoietin-like 4
  • 特异性This antibody is specific for ARP4.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human ARP4. 25 kDa protein containing 204 amino acid residues of the human ARP4 and 16 additional amino acid residues, HisTag. Source of immunogen, E. coli

性能

应用

Our Abpromise guarantee covers the use of ab47046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.

靶标

  • 功能Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • 组织特异性Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • 序列相似性Contains 1 fibrinogen C-terminal domain.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Angiopoietin like 4 antibody
    • Angiopoietin related protein 4 antibody
    • Angiopoietin-like protein 4 antibody
    • Angiopoietin-related protein 4 antibody
    • ANGL4_HUMAN antibody
    • ANGPT L2 antibody
    • ANGPT L4 antibody
    • ANGPTL2 antibody
    • Angptl4 antibody
    • ARP4 antibody
    • Fasting induced adipose factor antibody
    • FIAF antibody
    • HARP antibody
    • Hepatic angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin-related protein antibody
    • HFARP antibody
    • NL2 antibody
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody
    • PGAR antibody
    • pp1158 antibody
    • PPARG angiopoietin related protein antibody
    • PSEC0166 antibody
    • TGQTL antibody
    • UNQ171 antibody
    • Weakly similar to angiopoietin 1 [H.sapiens] antibody
    see all

Anti-Angiopoietin-like 4 antibody 图像

  • All lanes : Anti-Angiopoietin-like 4 antibody (ab47046) at 1 µg/ml

    Lane 1 : Recombinant protein 100 ng/Lane, Reducing
    Lane 2 : Recombinant protein 10 ng/Lane, Reducing
    Lane 3 : Recombinant protein 1 ng/Lane, Reducing
    Lane 4 : Recombinant protein 1 ng/Lane, Non-Reducing
    Lane 5 : Recombinant protein 10 ng/Lane, Non-Reducing
    Lane 6 : Recombinant protein 100 ng/Lane, Non-Reducing

    Secondary
    Anti-Rabbit HRP-Conjugate at 1/2000 dilution

    Predicted band size : 45 kDa

Anti-Angiopoietin-like 4 antibody (ab47046)参考文献

ab47046 has not yet been referenced specifically in any publications.

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