Anti-Angiopoietin-like 4抗体(ab115798)

概述

  • 产品名称Anti-Angiopoietin-like 4抗体
    参阅全部 Angiopoietin-like 4 一抗
  • 描述
    兔多克隆抗体to Angiopoietin-like 4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to an internal sequence of Human ARP4.

  • 阳性对照
    • Breast cancer tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab115798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.Can be blocked with Angiopoietin-like 4 peptide (ab123817). The detection limit for ARP4 is approximately 2.5ng/lane under non-reducing and reducing conditions.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • 组织特异性Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • 序列相似性Contains 1 fibrinogen C-terminal domain.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Angiopoietin like 4 antibody
    • Angiopoietin related protein 4 antibody
    • Angiopoietin-like protein 4 antibody
    • Angiopoietin-related protein 4 antibody
    • ANGL4_HUMAN antibody
    • ANGPT L2 antibody
    • ANGPT L4 antibody
    • ANGPTL2 antibody
    • Angptl4 antibody
    • ARP4 antibody
    • Fasting induced adipose factor antibody
    • FIAF antibody
    • HARP antibody
    • Hepatic angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin-related protein antibody
    • HFARP antibody
    • NL2 antibody
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody
    • PGAR antibody
    • pp1158 antibody
    • PPARG angiopoietin related protein antibody
    • PSEC0166 antibody
    • TGQTL antibody
    • UNQ171 antibody
    • Weakly similar to angiopoietin 1 [H.sapiens] antibody
    see all

Anti-Angiopoietin-like 4 antibody 图像

  • ab115798 at 1µg/ml staining ARP4 in by Paraffin-embedded Human breast cancer tissue by Immunohistochemistry,
  • All lanes : Anti-Angiopoietin-like 4 antibody (ab115798)

    Lane 1 : Smmc Whole Cell Lysate
    Lane 2 : A549 Whole Cell Lysate
    Lane 3 : U87 Whole Cell Lysate
    Lane 4 : 293T Whole Cell Lysate
    Lane 5 : SGC Whole Cell Lysate


    Predicted band size : 45 kDa

Anti-Angiopoietin-like 4 antibody (ab115798)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for contacting us.  We have added the blocking peptide for ab115798 to our catalog.  It is now listed as Angiopoietin-like 4 peptide - ab123817.  The lead time for this peptide is currently 3-4 weeks.  I hope this helps, please let me know if...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"