Anti-Angiopoietin 3抗体[RM0073-2H34] (ab86047)

概述

• 产品名称
  Anti-Angiopoietin 3抗体[RM0073-2H34]
• 描述
  大鼠单克隆抗体[RM0073-2H34] to Angiopoietin 3
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse
  
• 免疫原

  Mouse recombinant Angiopoietin 3.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• 纯度
  Protein A purified
• 纯化说明
  The IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and filter sterilised through a 0.2 µm filter.
• 克隆
  单克隆
• 克隆编号
  RM0073-2H34
• 同种型
  IgG2
• 研究领域
  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • Angiopoietin

相关产品

• Compatible Secondaries
  • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
  • Goat Anti-Rat IgG H&L (HRP) (ab205720)

应用

靶标

• 相关性
  Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. Angiopoietin 3 (ANG3), also called ANG4, might represent counterparts in mouse and human. Based on chromosomal analysis, mouse ANG3 is thought to be an ortholog of human ANG4. Human ANG4 acts as an agonist that binds and activates Tie2, whereas mouse ANG3 is likely to be a Tie2 antagonist, exerting agonist or antagonist activities depending on the cell context. Mouse ANG3 is expressed in various mouse tissues. Mouse angiopoietin 3 is a secreted glycoprotein and member of the angiopoietin family. It has an N terminal coiled-coil domain and a Cbterminal fibrinogen like domain. The coiled coil domains mediate ligand homo oligomerization and the fibrinogen like domains mediate ligand activity. Recombinant mouse angiopoietin 3 has a calculated molecular mass of 58 kDa. Due to glycosylation, the recombinant protein (containing 3 peptides) has an apparent molecular mass of 85-90 kDa in SDS-PAGE under reducing conditions. Mouse angiopoietin 3 shares 47%, 46%, and 54% sequence identity with mouse ANG1, mouse ANG2, and human ANG4, respectively.
• 细胞定位
  Secreted
• 数据库链接
  • Entrez Gene: 11602 Mouse
  • SwissProt: Q9WVH6 Mouse
• 别名
  • AGP4 antibody
  • ANG 3 antibody
  • ANG 4 antibody

  • ANG3 antibody
  • ANG4 antibody
  • Angiopoietin 4 antibody
  • ANGPT 4 antibody
  • ANGPT4 antibody
  • MGC138181 antibody
  • MGC138183 antibody

  see all

实验方案

• Western blot protocols