Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Belongs to the angiomotin family.
The coiled coil domain interacts directly with the BAR domain of ARHGAP17. The angiostatin binding domain (871-1005) allows the binding to angiostatin.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cell junction > tight junction. Localized on the cell surface. May act as a transmembrane protein.
Detection of Angiomotin by Western Blot of Immunprecipitate.
ab117776 at 1µg/ml staining Angiomotin in 293T whole cell lysate immunoprecipitated using ab117776 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 1 second.