Inhibits HAT activity of p300 and p300/CREB-binding protein-associated factor (pCAF) (IC50 = 8.5 and 5 μM, respectively). Suppresses NF-κB activation, inhibits IκBα phosphorylation and prohibits p65 nuclear translocation
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Soluble in ethanol to 25 mM and in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Omanakuttan A et al. Anacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. Mol Pharmacol82:614-22 (2012).
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Sung B et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. Blood111:4880-91 (2008).
Read more (PubMed: 18349320) »