Anti-Amyloid Precursor Protein Frameshift Mutant抗体(ab2085)

概述

  • 产品名称Anti-Amyloid Precursor Protein Frameshift Mutant抗体
    参阅全部 Amyloid Precursor Protein Frameshift Mutant 一抗
  • 描述
    山羊多克隆抗体to Amyloid Precursor Protein Frameshift Mutant
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Amyloid Precursor Protein Frameshift Mutant aa 339-348 (C terminal). Frameshift sequence from Figure 1, van Leeuwen, et.al., Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer’s and Down Patients, Science, Vol. 279, 9 Jan 1998, 242-247.

性能

应用

Our Abpromise guarantee covers the use of ab2085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
WB 1/3000. Detects a band of approximately 45 kDa.
IHC-P 1/300.

靶标

  • 相关性Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimers disease patients and Downs Syndrome patients.
  • 细胞定位Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus
  • 数据库链接
  • 别名
    • AAA antibody
    • ABETA antibody
    • ABPP antibody
    • AD1 antibody
    • APP antibody
    • APPI antibody
    see all

Anti-Amyloid Precursor Protein Frameshift Mutant antibody (ab2085)参考文献

ab2085 has not yet been referenced specifically in any publications.

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