Anti-Amyloid Precursor Protein Frameshift Mutant抗体(ab17365)

概述

  • 产品名称Anti-Amyloid Precursor Protein Frameshift Mutant抗体
    参阅全部 Amyloid Precursor Protein Frameshift Mutant 一抗
  • 描述
    山羊多克隆抗体to Amyloid Precursor Protein Frameshift Mutant
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Amyloid Precursor Protein Frameshift Mutant aa 339-348. Frameshift sequence from Figure 1, van Leeuwen, et.al., Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer’s and Down Patients, Science, Vol. 279, 9 Jan 1998, 242-247.
    Sequence:

    RGRTSSKELA

性能

  • 形式Liquid
  • 存放说明Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    Mix suspension via gentle inversion before use.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: Defibrinated whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab17365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
WB 1/3000. Predicted molecular weight: 1 kDa.
IHC-P 1/300.

靶标

  • 相关性Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimers disease patients and Downs Syndrome patients.
  • 细胞定位Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus
  • 数据库链接
  • 别名
    • AAA antibody
    • ABETA antibody
    • ABPP antibody
    • AD1 antibody
    • APP antibody
    • APPI antibody
    see all

Anti-Amyloid Precursor Protein Frameshift Mutant antibody (ab17365)参考文献

This product has been referenced in:
  • Xu N  et al. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive ß-catenin Signaling Pathway. Int J Med Sci 12:524-9 (2015). WB ; Human . Read more (PubMed: 26078714) »

See 1 Publication for this product

Product Wall

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