RabMAb

Anti-AMSH抗体[EPR4361] (ab108301)

概述

  • 产品名称Anti-AMSH抗体[EPR4361]
    参阅全部 AMSH 一抗
  • 描述
    兔单克隆抗体[EPR4361] to AMSH
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide, corresponding to residues in human AMSH

  • 阳性对照
    • Jurkat cell lysate, HeLa cell lysate, Raji cell lysate, SW480 cell lysate
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab108301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
ICC 1/100 - 1/250.

靶标

  • 功能Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the peptidase M67C family.
    Contains 1 MPN (JAB/Mov34) domain.
  • 结构域The JAMM motif is essential for the protease activity.
  • 翻译后修饰Phosphorylated after BMP type I receptor activation.
    Ubiquitinated by SMURF2 in the presence of RNF11.
  • 细胞定位Nucleus. Membrane. Cytoplasm. Early endosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMSH antibody
    • Associated molecule with the SH3 domain of STAM antibody
    • Endosome associated ubiquitin isopeptidase antibody
    • Endosome-associated ubiquitin isopeptidase antibody
    • MGC126516 antibody
    • MGC126518 antibody
    • MICCAP antibody
    • STABP_HUMAN antibody
    • STAM binding protein antibody
    • STAM-binding protein antibody
    • Stambp antibody
    see all

Anti-AMSH antibody [EPR4361] 图像

  • All lanes : Anti-AMSH antibody [EPR4361] (ab108301) at 1/1000 dilution

    Lane 1 : Jurkat cell lysate
    Lane 2 : HeLa cell lysate
    Lane 3 : Raji cell lysate
    Lane 4 : SW480 cell lysate

    Lysates/proteins at 10 µg per lane.


    Performed under reducing conditions.

    Predicted band size : 48 kDa

Anti-AMSH antibody [EPR4361] (ab108301)参考文献

ab108301 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"