概述

  • 产品名称Anti-AMSH抗体
    参阅全部 AMSH 一抗
  • 描述
    兔多克隆抗体to AMSH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 362-391 of Human AMSH (NP_964010.1, NP_998787.1, NP_006454.1).

  • 阳性对照
    • A549 cell line lysates, mouse cerebellum tissue lysates

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab113053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 48 kDa.

靶标

  • 功能Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the peptidase M67C family.
    Contains 1 MPN (JAB/Mov34) domain.
  • 结构域The JAMM motif is essential for the protease activity.
  • 翻译后修饰Phosphorylated after BMP type I receptor activation.
    Ubiquitinated by SMURF2 in the presence of RNF11.
  • 细胞定位Nucleus. Membrane. Cytoplasm. Early endosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMSH antibody
    • Associated molecule with the SH3 domain of STAM antibody
    • Endosome associated ubiquitin isopeptidase antibody
    • Endosome-associated ubiquitin isopeptidase antibody
    • MGC126516 antibody
    • MGC126518 antibody
    • MICCAP antibody
    • STABP_HUMAN antibody
    • STAM binding protein antibody
    • STAM-binding protein antibody
    • Stambp antibody
    see all

Anti-AMSH antibody 图像

  • Anti-AMSH antibody (ab113053) at 1/100 dilution + A549 cell line lysates at 35 µg

    Predicted band size : 48 kDa
  • Anti-AMSH antibody (ab113053) at 1/100 dilution + Mouse cerebellum tissue lysates at 35 µg

    Predicted band size : 48 kDa

Anti-AMSH antibody (ab113053)参考文献

ab113053 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113053.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"