Anti-Amphiregulin抗体(ab2993)

概述

  • 产品名称Anti-Amphiregulin抗体
    参阅全部 Amphiregulin 一抗
  • 描述
    兔多克隆抗体to Amphiregulin
  • 经测试应用适用于: IPmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A synthetic 19 mer peptide, corresponding to amino acids 8 - 26 (

    VKPPQNKTESENTSDKPKR

    ) from the secretedamphiregulin of human origin.

  • 阳性对照
    • LS174T cells
  • 常规说明


    Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.40
    Constituents: 0.0268% PBS, 0.2% BSA
  • Concentration information loading...
  • 纯度Protein A purified
  • Primary antibody说明Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab2993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 10 µg/mg of lysate.

With protein A, native.

靶标

Anti-Amphiregulin antibody (ab2993)参考文献

ab2993 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. We would like to confirm that this primary antibody is un-conjugated therefore you need an HRP-linked secondary antibody. The recommended compatible secondary antibodies are listed on the bottom section of the on-line da...

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Thank you for your enquiry. The ab2993 Amphiregulin antibody recognizes a synthetic 19 mer peptide, corresponding to amino acids 8 - 26 (VKPPQNKTESENTSDKPKR) from the secretedamphiregulin of human origin. If that amino acid sequence is present in the ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"