概述

  • 产品名称Anti-AMPD3抗体
    参阅全部 AMPD3 一抗
  • 描述
    兔多克隆抗体to AMPD3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 541-776 of Human AMPD3 (BC126118).

  • 阳性对照
    • Human fetal kidney lysate; Human fetal skeletal muscle tissue.

性能

  • 形式Lyophilised:Reconstitute in 200ul sterile water
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab118230 is purified by a protein affinity column.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 89 kDa (predicted molecular weight: 89 kDa).
IHC-P 1/100 - 1/500.

靶标

  • 功能AMP deaminase plays a critical role in energy metabolism.
  • 组织特异性Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.
  • 通路Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
  • 疾病相关Defects in AMPD3 are the cause of adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE) [MIM:612874]; also known as erythrocyte AMP deaminase deficiency. AMPDDE is a metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders.
  • 序列相似性Belongs to the adenosine and AMP deaminases family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Adenosine monophosphate deaminase (isoform E) antibody
    • Adenosine monophosphate deaminase 3 antibody
    • AMP aminohydrolase antibody
    • AMP deaminase 3 antibody
    • AMP deaminase isoform E antibody
    • Ampd3 antibody
    • AMPD3_HUMAN antibody
    • Erythrocyte AMP deaminase antibody
    • Erythrocyte specific AMP deaminase antibody
    • Erythrocyte specific protein antibody
    • Erythrocyte type AMP deaminase antibody
    • Erythroid Marker antibody
    • Myoadenylate deaminase antibody
    • OTTHUMP00000230743 antibody
    • OTTHUMP00000230746 antibody
    • OTTHUMP00000230747 antibody
    • OTTHUMP00000230748 antibody
    • OTTHUMP00000230749 antibody
    see all

Anti-AMPD3 antibody 图像

  • Anti-AMPD3 antibody (ab118230) at 1/1000 dilution + Human fetal kidney lysate

    Predicted band size : 89 kDa
  • ab118230 at 1/100 dilution staining AMPD3 in Formalin-fixed, Paraffin-embedded Human fetal skeletal muscle tissue by Immunohistochemistry.Note cytoplasmic staining.

Anti-AMPD3 antibody (ab118230)参考文献

ab118230 has not yet been referenced specifically in any publications.

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