概述

  • 产品名称AMN082 dihydrochloride
  • 描述
    mGlu7 agonist
  • 生物学描述Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.
  • 纯度> 99%

性能

    实验方案

    AMN082 dihydrochloride (ab120011)参考文献

    This product has been referenced in:
    • Pelkey KA  et al. mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. Neuropharmacology 52:108-17 (2007). Read more (PubMed: 16914173) »
    • Suzuki G  et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-56 (2007). Read more (PubMed: 17609420) »
    • Mitsukawa K  et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A 102:18712-7 (2005). Read more (PubMed: 16339898) »

    See all 10 Publications for this product

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    Thank you for your enquiry regarding ab120011.

    We weigh to a tolerance of +5% for the 50mg pack sizes so there is always at least 50mg in but there may be up to 52.5mg. On average it is likely to be somewhere in between – estimated to b...

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    Thank you for your reply. I apologize about this mistake.

    ab120011 is AMN082 dihydrochloride. The country of manufacture is Great Britain.

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