概述

  • 产品名称Anti-AMN抗体
    参阅全部 AMN 一抗
  • 描述
    兔多克隆抗体to AMN
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (NWSQNRTPCA GGAVEFPADK MVSVLVQEGH AVSDMLLPLD GELVLASGAG) of Human AMN (NP_112205).

  • 阳性对照
    • Human fetal liver lysate

性能

应用

Our Abpromise guarantee covers the use of ab105806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.
  • 组织特异性Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes.
  • 疾病相关Defects in AMN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM:261100]; also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
  • 序列相似性Contains 1 VWFC domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5033428N14Rik antibody
    • amn antibody
    • Amnion associated transmembrane protein antibody
    • Amnionless antibody
    • Amnionless homolog antibody
    • AMNLS_HUMAN antibody
    • AV002116 antibody
    • PRO1028 antibody
    • Protein amnionless antibody
    • Type I transmembrane protein antibody
    • UNQ513/PRO1028 antibody
    • Visceral endoderm specific type 1 transmembrane protein antibody
    see all

Anti-AMN antibody 图像

  • Anti-AMN antibody (ab105806) at 1 µg/ml + Human fetal liver lysate at 10 µg

    Predicted band size : 46 kDa

Anti-AMN antibody (ab105806)参考文献

ab105806 has not yet been referenced specifically in any publications.

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