Anti-Amino-terminal enhancer of split抗体(ab118881)

概述

  • 产品名称Anti-Amino-terminal enhancer of split抗体
    参阅全部 Amino-terminal enhancer of split 一抗
  • 描述
    兔多克隆抗体to Amino-terminal enhancer of split
  • 经测试应用适用于: WB, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    A KLH conjugated, 16 amino acid synthetic peptide from near the C terminus of Human Amino-terminal enhancer of split.

  • 阳性对照
    • Human skeletal muscle

性能

应用

Our Abpromise guarantee covers the use of ab118881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC Use at an assay dependent concentration.

靶标

  • 功能Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
  • 组织特异性Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
  • 序列相似性Belongs to the WD repeat Groucho/TLE family.
  • 结构域Lacks the C-terminal WD repeats.
  • 翻译后修饰Ubiquitinated by XIAP/BIRC4.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aes 1 antibody
    • Aes 2 antibody
    • aes antibody
    • AES_HUMAN antibody
    • Aes1 antibody
    • Aes2 antibody
    • Amino enhancer of split antibody
    • Amino terminal enhancer of split antibody
    • Amino-terminal enhancer of split antibody
    • Esp 1 antibody
    • Esp1 antibody
    • Gp130 associated protein GAM antibody
    • Gp130-associated protein GAM antibody
    • GRG 5 antibody
    • GRG antibody
    • GRG protein antibody
    • Grg-5 antibody
    • GRG5 antibody
    • Groucho-related protein 5 antibody
    • Protein ESP 1 antibody
    • Protein ESP1 antibody
    • Protein GRG antibody
    • TLE 5 antibody
    • TLE5 antibody
    see all

Anti-Amino-terminal enhancer of split antibody 图像

  • Human skeletal muscle (formalin fixed, paraffin embedded) stained with ab118881 at 2.5 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Amino-terminal enhancer of split antibody (ab118881)参考文献

ab118881 has not yet been referenced specifically in any publications.

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