Anti-Amino-terminal enhancer of split抗体(ab118280)

概述

  • 产品名称Anti-Amino-terminal enhancer of split抗体
    参阅全部 Amino-terminal enhancer of split 一抗
  • 描述
    山羊多克隆抗体to Amino-terminal enhancer of split
  • 特异性ab118280 is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    SHLPQQLKFTTSD

    by a Cysteine residue linker, corresponding to N terminal amino acids 12-24 of Human Amino-terminal enhancer of split (NP_945320.1; NP_001121.2; NP_945321.1).

  • 阳性对照
    • Human Brain (Cerebellum and Cerebral Cortex) lysates.

性能

应用

Our Abpromise guarantee covers the use of ab118280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 21 kDa).

靶标

  • 功能Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
  • 组织特异性Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
  • 序列相似性Belongs to the WD repeat Groucho/TLE family.
  • 结构域Lacks the C-terminal WD repeats.
  • 翻译后修饰Ubiquitinated by XIAP/BIRC4.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aes 1 antibody
    • Aes 2 antibody
    • aes antibody
    • AES_HUMAN antibody
    • Aes1 antibody
    • Aes2 antibody
    • Amino enhancer of split antibody
    • Amino terminal enhancer of split antibody
    • Amino-terminal enhancer of split antibody
    • Esp 1 antibody
    • Esp1 antibody
    • Gp130 associated protein GAM antibody
    • Gp130-associated protein GAM antibody
    • GRG 5 antibody
    • GRG antibody
    • GRG protein antibody
    • Grg-5 antibody
    • GRG5 antibody
    • Groucho-related protein 5 antibody
    • Protein ESP 1 antibody
    • Protein ESP1 antibody
    • Protein GRG antibody
    • TLE 5 antibody
    • TLE5 antibody
    see all

Anti-Amino-terminal enhancer of split antibody 图像

  • Anti-Amino-terminal enhancer of split antibody (ab118280) at 0.3 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 21 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

Anti-Amino-terminal enhancer of split antibody (ab118280)参考文献

ab118280 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118280.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"